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Myeloperoxidase |61440|
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“Myeloperoxidase (MPO)”  

Myeloperoxidase

  In biochemistry, Myeloperoxidase (MPO), a hemeprotein peroxiductase (peroxidase) synthesized by leukocytes, is an oxidoreductase enzyme reaction which catalyzes the conversion of a donor and peroxide to an oxidized donor and water.
  In our body, the presence of hydrogen peroxide, myeloperoxidase will generate hypochlorous acid and singlet oxygen, a reaction that plays an important role in the killing of bacteria by phagocytes. *
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References & Citations:
1. Young IS. et al "Antioxidants in health and disease"   J Clin Pathol. 2001 Mar;54(3):176-86  
2. Goedken M. et al "Impact of two novel mutations on the structure and function of human myeloperoxidase"   J Biol Chem. 2007 Sep 21;282(38):27994-8003  
3. Grune T. et al "Beta-carotene is an important vitamin A source for humans"   J Nutr. 2010 Dec;140(12):2268S-2285S  
4. Fidler AL. et al "A unique covalent bond in basement membrane is a primordial innovation for tissue evolution"   Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):331-6  
 
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